The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: 1/10000. WB: 1/5000. Predicted molecular weight: 48 kDa. Dilution optimised using Chromogenic detection. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
Expressed in the prostate gland and prostate cancers.
Belongs to the peptidase S1 family. Contains 1 EGF-like domain. Contains 1 kringle domain. Contains 1 peptidase S1 domain.
Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
Schroder WA et al. Tumor cell-expressed SerpinB2 is present on microparticles and inhibits metastasis. Cancer Med3:500-13 (2014).
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Hasegawa Y et al. Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-ß gene. Mol Ther18:1778-86 (2010).
Read more (PubMed: 20606645) »