Key features and details
- Rabbit polyclonal to Urokinase (Biotin)
- Suitable for: ELISA, RIA, IP, WB
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
Product nameAnti-Urokinase antibody (Biotin)
See all Urokinase primary antibodies
DescriptionRabbit polyclonal to Urokinase (Biotin)
Tested applicationsSuitable for: ELISA, RIA, IP, WBmore details
Species reactivityReacts with: Human
Full length native ATF uPA purified from plasma (Human)
ATF is the amino terminal fragment of urokinase (uPA) corresponding to amino acid residues 1-135. uPA-ATF contains the growth factor like domain, which binds to the urokinase receptor, and the kringle domain which is involved in the induction of cell chemotaxis by urokinase. ATF inhibits the binding of urokinase to its receptor uPAR and acts as a broad inhibitor of cell migration.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.50
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityProtein G purified
Primary antibody notesATF is the amino terminal fragment of urokinase (uPA) corresponding to amino acid residues 1-135. uPA-ATF contains the growth factor like domain, which binds to the urokinase receptor, and the kringle domain which is involved in the induction of cell chemotaxis by urokinase. ATF inhibits the binding of urokinase to its receptor uPAR and acts as a broad inhibitor of cell migration.
Our Abpromise guarantee covers the use of ab49577 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use at an assay dependent dilution.|
|RIA||Use at an assay dependent dilution.|
|IP||Use at an assay dependent dilution.|
|WB||Use at an assay dependent dilution. Detects a band of approximately N\A kDa.|
FunctionSpecifically cleave the zymogen plasminogen to form the active enzyme plasmin.
Tissue specificityExpressed in the prostate gland and prostate cancers.
Sequence similaritiesBelongs to the peptidase S1 family.
Contains 1 EGF-like domain.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain.
modificationsPhosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
- Information by UniProt
- ATF antibody
- ATF uPA antibody
- BDPLT5 antibody
ab49577 has not yet been referenced specifically in any publications.