Overview

  • Product name

    Anti-Urokinase antibody (Biotin)
    See all Urokinase primary antibodies
  • Description

    Rabbit polyclonal to Urokinase (Biotin)
  • Host species

    Rabbit
  • Conjugation

    Biotin
  • Tested applications

    Suitable for: ELISA, RIA, IP, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native ATF uPA purified from plasma (Human)

  • General notes


    ATF is the amino terminal fragment of urokinase (uPA) corresponding to amino acid residues 1-135. uPA-ATF contains the growth factor like domain, which binds to the urokinase receptor, and the kringle domain which is involved in the induction of cell chemotaxis by urokinase. ATF inhibits the binding of urokinase to its receptor uPAR and acts as a broad inhibitor of cell migration.

Properties

Applications

Our Abpromise guarantee covers the use of ab49577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Detects a band of approximately N\A kDa.

Target

  • Function

    Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
  • Tissue specificity

    Expressed in the prostate gland and prostate cancers.
  • Sequence similarities

    Belongs to the peptidase S1 family.
    Contains 1 EGF-like domain.
    Contains 1 kringle domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications

    Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • ATF antibody
    • ATF uPA antibody
    • BDPLT5 antibody
    • Plasminogen activator antibody
    • Plasminogen activator urinary antibody
    • Plasminogen activator urokinase antibody
    • PLAU antibody
    • QPD antibody
    • u PA antibody
    • U plasminogen activator antibody
    • u-PA antibody
    • U-plasminogen activator antibody
    • uPA antibody
    • URK antibody
    • UROK_HUMAN antibody
    • Urokinase plasminogen activator antibody
    • Urokinase type plasminogen activator antibody
    • Urokinase type plasminogen activator precursor antibody
    • Urokinase-type plasminogen activator chain B antibody
    see all

References

ab49577 has not yet been referenced specifically in any publications.

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