Key features and details
- Rabbit polyclonal to Uroplakin III
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Uroplakin III antibody
See all Uroplakin III primary antibodies
DescriptionRabbit polyclonal to Uroplakin III
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Synthetic peptide within Human Uroplakin III aa 250 to the C-terminus (C terminal). The exact sequence is proprietary.
Database link: O75631
- Human Bladder
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab82173 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
|WB||Use at an assay dependent concentration.|
FunctionComponent of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
Tissue specificityExpressed in ureter.
Involvement in diseaseDefects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.
Sequence similaritiesBelongs to the uroplakin-3 family.
Cellular localizationEndoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
- Information by UniProt
- MGC119178 antibody
- OTTHUMP00000028951 antibody
- UP III antibody
ab82173 has been referenced in 3 publications.
- Jafree DJ et al. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease. Elife 8:N/A (2019). PubMed: 31808745
- Hou T et al. Aberrant differentiation of urothelial cells in patients with ureteropelvic junction obstruction. Int J Clin Exp Pathol 7:5837-45 (2014). IF ; Human . PubMed: 25337225
- Hicks AN et al. Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): Consequences for mouse bladder development and function. Neurourol Urodyn : (2013). PubMed: 23371862