• Product name

    Anti-URP2/Kindlin-3 antibody
    See all URP2/Kindlin-3 primary antibodies
  • Description

    Rabbit polyclonal to URP2/Kindlin-3
  • Host species

  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human URP2/Kindlin-3 aa 106-371.
    Database link: Q86UX7

  • Positive control

    • WB: Jurkat and Raji whole cell lysates. ICC/IF: Jurkat cells. IHC-P: Rat RT2 xenograft; Human gastric cancer tissue.
  • General notes

    Previously labelled as URP2. 



Our Abpromise guarantee covers the use of ab126900 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 75 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.


  • Function

    Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).
    Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
  • Tissue specificity

    Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
  • Involvement in disease

    Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3) [MIM:612840]; also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes.
  • Sequence similarities

    Belongs to the kindlin family.
    Contains 1 FERM domain.
    Contains 1 PH domain.
  • Domain

    The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
  • Cellular localization

    Cell projection > podosome. Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • Fermitin family homolog 3 antibody
    • Fermitin family member 3 antibody
    • FERMT3 antibody
    • Kind3 antibody
    • Kindlin 3 antibody
    • Kindlin-3 antibody
    • Kindlin3 antibody
    • MGC10966 antibody
    • MIG 2 antibody
    • MIG2 like protein antibody
    • MIG2-like protein antibody
    • MIG2B antibody
    • Unc 112 related protein 2 antibody
    • Unc-112-related protein 2 antibody
    • UNC112C antibody
    • URP2 antibody
    • URP2_HUMAN antibody
    • URP2SF antibody
    see all


  • ab126900, at 1/500 dilution, staining URP2/Kindlin-3 in paraffin-embedded Human gastric cancer tissue by Immunohistochemistry.

  • All lanes : Anti-URP2/Kindlin-3 antibody (ab126900) at 1/1000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 75 kDa

    7.5% SDS-PAGE
  • 4% paraformaldehyde-fixed Jurkat (human T cell leukemia cell line from peripheral blood) cells labeling URP2/Kindlin-3 using ab126900 at 1/500 dilution (green) in ICC/IF.

    The nuclear counter stain is Hoechst 33342 (blue).

  • ab126900, at 1/500 dilution, staining URP2/Kindlin-3 in paraffin-embedded RT2 xenograft tissue by Immunohistochemistry.


ab126900 has not yet been referenced specifically in any publications.

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