Overview

  • Product name
    Ursodiol, Endogenous bile acid
  • Description
    Endogenous bile acid
  • Biological description
    Endogenous bile acid. Colon chemopreventive agent. Promotes bile flow, reduces hepatic inflammation and shows antiapoptotic effects. Reduces cholestatic hepatopathies in vivo. Attenuates colonic epithelial secretory function. Orally active.
  • CAS Number
    128-13-2
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethyl-2,-3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
  • Molecular weight
    392.57
  • Molecular formula
    C24H40O4
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1[C@H](C[C@@]2([C@](C1)([C@]3([C@@]([C@H](C2)O)([C@]4([C@](CC3)([C@@](CC4)([C@H](C)CCC(O)=O)[H])C)[H])[H])[H])C)[H])O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Kelly OB  et al. Ursodeoxycholic acid attenuates colonic epithelial secretory function. J Physiol 591:2307-18 (2013). Read more (PubMed: 23507881) »
  • Wang R  et al. Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol 305:G286-94 (2013). Read more (PubMed: 23764895) »
  • Roma MG  et al. Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications. Clin Sci (Lond) 121:523-44 (2011). Read more (PubMed: 21854363) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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