• Product name

    Anti-USH1C/Harmonin antibody
    See all USH1C/Harmonin primary antibodies
  • Description

    Goat polyclonal to USH1C/Harmonin
  • Host species

  • Specificity

    This antibody is expected to recognize both reported isoforms (NP_005700.2 and NP_710142.1).
  • Tested applications

    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human USH1C/Harmonin aa 2-14 (N terminal).


  • Positive control

    • Human Kidney fibroblast cell line 293 lysates.
  • General notes

     This product was previously labelled as USH1C



  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab19045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 75 kDa.
ELISA 1/32000.
IHC-P Use a concentration of 10 µg/ml.


  • Function

    May be involved in protein-protein interaction.
  • Tissue specificity

    Expressed in small intestine, colon, kidney, eye and weakly in pancreas. Expressed also in vestibule of the inner ear.
  • Involvement in disease

    Defects in USH1C are the cause of Usher syndrome type 1C (USH1C) [MIM:276904]; also known as Usher syndrome type I Acadian variety. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
    Defects in USH1C are the cause of deafness autosomal recessive type 18 (DFNB18) [MIM:602092]. DFNB18 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • Sequence similarities

    Contains 3 PDZ (DHR) domains.
  • Domain

    The PDZ domain 1 mediates interactions with USH1G/SANS and SLC4A7.
  • Information by UniProt
  • Database links

  • Alternative names

    • AIE 75 antibody
    • AIE75 antibody
    • Antigen NY CO 38/NY CO 37 antibody
    • Antigen NY-CO-38/NY-CO-37 antibody
    • Autoimmune enteropathy related antigen AIE 75 antibody
    • Autoimmune enteropathy related antigen AIE75 antibody
    • Autoimmune enteropathy-related antigen AIE-75 antibody
    • Deafness autosomal recessive 18 antibody
    • DFNB 18 antibody
    • DFNB18 antibody
    • Harmonin antibody
    • NY CO 37 antibody
    • NY CO 38 antibody
    • PDZ 45 antibody
    • PDZ 73 antibody
    • PDZ 73 protein antibody
    • PDZ 73/NY CO 38 antibody
    • PDZ45 antibody
    • PDZ73 antibody
    • PDZ73 protein antibody
    • Protein PDZ-73 antibody
    • Renal carcinoma antigen NY REN 3 antibody
    • Renal carcinoma antigen NY-REN-3 antibody
    • USH 1C antibody
    • USH1C antibody
    • USH1C_HUMAN antibody
    • Ush1cpst antibody
    • Usher syndrome 1C (autosomal recessive severe) antibody
    • Usher syndrome 1C antibody
    • Usher syndrome type 1C protein antibody
    • Usher syndrome type-1C protein antibody
    see all


  • ab19045 (1µg/ml) staining of 293 lysate (35µg protein in RIPA buffer) approx. 75kDa.  Primary incubation was 1 hour.  Detected by chemiluminescence.

    ab19045 (1µg/ml) staining of 293 lysate (35µg protein in RIPA buffer) approx. 75kDa. Primary incubation was 1 hour. Detected by chemiluminescence.
  • ab19045 (10µg/ml) staining of Human Kidney by IHC-P. Microwaved antigen retrieval with citrate buffer (pH 6), HRP-staining.


This product has been referenced in:

  • Tian C  et al. Ush1c gene expression levels in the ear and eye suggest different roles for Ush1c in neurosensory organs in a new Ush1c knockout mouse. Brain Res 1328:57-70 (2010). Read more (PubMed: 20211154) »
See 1 Publication for this product

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