Anti-USP19 antibody (ab167059)
Key features and details
- Rabbit polyclonal to USP19
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-USP19 antibody
See all USP19 primary antibodies -
Description
Rabbit polyclonal to USP19 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide derived from internal sequence of Human USP19.
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Positive control
- NIH3T3 cell extract; Human heart tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
PBS without Mg2+ and Ca2+. -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab167059 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 146 kDa.
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| IHC-P |
Use a concentration of 5 µg/ml.
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| Notes |
|---|
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WB
1/500 - 1/1000. Predicted molecular weight: 146 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. |
Target
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Function
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. -
Sequence similarities
Belongs to the peptidase C19 family.
Contains 2 CS domains.
Contains 1 MYND-type zinc finger. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 10869 Human
- Entrez Gene: 71472 Mouse
- Omim: 614471 Human
- SwissProt: O94966 Human
- SwissProt: Q3UJD6 Mouse
- Unigene: 255596 Human
- Unigene: 289706 Mouse
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Alternative names
- 8430421I07Rik antibody
- AI047774 antibody
- Deubiquitinating enzyme 19 antibody
see all
Images
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Western blot - Anti-USP19 antibody (ab167059)All lanes : Anti-USP19 antibody (ab167059) at 1/500 dilution
Lane 1 : NIH3T3 cell extract
Lane 2 : NIH3T3 cell extract with immunizing peptide
Predicted band size: 146 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USP19 antibody (ab167059)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling USP19 with ab167059 at 5 µg/ml.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab167059 has not yet been referenced specifically in any publications.