Overview

  • Product name

  • Description

    Mouse polyclonal to USP19
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full-length Human protein (NP_006668.1, aa 1-1318).

  • Positive control

    • USP19-transfected 293T cells lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab68527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 175 kDa (predicted molecular weight: 145 kDa).

Target

  • Function

    Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates.
  • Sequence similarities

    Belongs to the peptidase C19 family.
    Contains 2 CS domains.
    Contains 1 MYND-type zinc finger.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 8430421I07Rik antibody
    • AI047774 antibody
    • Deubiquitinating enzyme 19 antibody
    • Ubiquitin carboxyl terminal hydrolase 19 antibody
    • Ubiquitin carboxyl-terminal hydrolase 19 antibody
    • Ubiquitin specific peptidase 19 antibody
    • Ubiquitin specific processing protease 19 antibody
    • Ubiquitin specific protease 19 antibody
    • Ubiquitin thioesterase 19 antibody
    • Ubiquitin thiolesterase 19 antibody
    • Ubiquitin-specific-processing protease 19 antibody
    • UBP19_HUMAN antibody
    • Usp19 antibody
    • Zinc finger MYND domain containing protein 9 antibody
    • Zinc finger MYND domain-containing protein 9 antibody
    • ZMYND9 antibody
    see all

Images

  • All lanes : Anti-USP19 antibody (ab68527) at 1/500 dilution

    Lane 1 : transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size: 145 kDa
    Observed band size: 175 kDa
    why is the actual band size different from the predicted?

References

This product has been referenced in:

  • Bernadotte A  et al. In silico identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network. FEBS Open Bio 8:1830-1843 (2018). Read more (PubMed: 30410862) »
See 1 Publication for this product

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