Product nameAnti-USP19 antibody
See all USP19 primary antibodies
DescriptionRabbit polyclonal to USP19
SpecificityUSP19 antibody detects endogenous levels of total USP19 protein.
Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Synthetic peptide derived from an internal region of Human USP19
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab93159 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/50 - 1/100.
WB: 1/500 - 1/1000. Predicted molecular weight: 145 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionDeubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates.
Sequence similaritiesBelongs to the peptidase C19 family.
Contains 2 CS domains.
Contains 1 MYND-type zinc finger.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
- 8430421I07Rik antibody
- AI047774 antibody
- Deubiquitinating enzyme 19 antibody
This product has been referenced in:
- Gierisch ME et al. USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth. Sci Rep 9:951 (2019). Read more (PubMed: 30700749) »
- Ogawa M et al. 17ß-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor a. J Biol Chem 286:41455-65 (2011). WB ; Mouse . Read more (PubMed: 21971047) »