Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates.
Belongs to the peptidase C19 family. Contains 2 CS domains. Contains 1 MYND-type zinc finger.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Ogawa M et al. 17ß-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor a. J Biol Chem286:41455-65 (2011).
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