Overview

  • Product name

  • Description

    Rabbit polyclonal to USP2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide raised against c-terminal domain of Human USP2, conjugated to KLH.

  • Positive control

    • Human placenta, Human testis

Properties

Applications

Our Abpromise guarantee covers the use of ab101609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Requires pretreatment with proteinase K.

Target

  • Function

    Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.
  • Tissue specificity

    Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
  • Sequence similarities

    Belongs to the peptidase C19 family. USP2 subfamily.
  • Domain

    The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
  • Cellular localization

    Nucleus and Cytoplasm. Cytoplasm > perinuclear region. Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 41 kDa ubiquitin specific protease antibody
    • 41 kDa ubiquitin-specific protease antibody
    • Deubiquitinating enzyme 2 antibody
    • Ubiquitin carboxyl terminal hydrolase 2 antibody
    • Ubiquitin carboxyl-terminal hydrolase 2 antibody
    • ubiquitin specific peptidase 2 antibody
    • Ubiquitin specific processing protease 2 antibody
    • Ubiquitin specific protease 12 antibody
    • Ubiquitin specific protease 9 antibody
    • Ubiquitin specific protease, 41kD antibody
    • Ubiquitin thioesterase 2 antibody
    • Ubiquitin thiolesterase 2 antibody
    • Ubiquitin-specific-processing protease 2 antibody
    • Ubiquitin-specific-processing protease testis antibody
    • UBP-t antibody
    • UBP2_HUMAN antibody
    • UBP41 antibody
    • USP2 antibody
    • USP9 antibody
    see all

Images

  • ab101609 at 5 µg/ml staining USP2 in Human placenta by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab101609 at 5 µg/ml staining USP2 in Human testis by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

References

This product has been referenced in:

  • Wei T  et al. Ubiquitin-specific protease 2 decreases p53-dependent apoptosis in cutaneous T-cell lymphoma. Oncotarget 7:48391-48400 (2016). Read more (PubMed: 27351221) »
See 1 Publication for this product

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