Key features and details
- Rat monoclonal [94B] to v-cyclin
- Suitable for: IP, WB, ICC/IF
- Reacts with: Species independent
- Isotype: IgG
Product nameAnti-v-cyclin antibody [94B]
DescriptionRat monoclonal [94B] to v-cyclin
Tested applicationsSuitable for: IP, WB, ICC/IFmore details
Species reactivityReacts with: Species independent
Fusion protein corresponding to v-cyclin.
This product was previously labelled as HHV8 Cyclin
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab12208 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent dilution.|
|WB||Use at an assay dependent dilution. Detects a band of approximately 30 kDa.|
|ICC/IF||Use at an assay dependent dilution.|
RelevanceHHV8 is associated with the develpment of Kaposi's Sarcoma and a number of B cell lymphomas in AIDS patients. HHV8 encodes a viral (v) cyclin homologous to cellular D type cyclins, a class of positive cell cycle regulators that are physiologically modulated by the p27(Kip1) cell cycle inhibitor.
- HHV 8 cyclin antibody
- HHV 8c antibody
- Human Herpesvirus 8 ORF72 antibody
ab12208 has been referenced in 5 publications.
- Morrison K et al. The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. Cell Rep 29:2961-2969.e6 (2019). PubMed: 31801064
- Nayar U et al. Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies. J Clin Invest 127:2066-2080 (2017). PubMed: 28504647
- Sharma-Walia N et al. The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. J Virol 88:2131-56 (2014). PubMed: 24335295
- Sin SH & Dittmer DP Viral latency locus augments B-cell response in vivo to induce chronic marginal zone enlargement, plasma cell hyperplasia, and lymphoma. Blood 121:2952-63 (2013). PubMed: 23365457
- Platt GM et al. Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines. Virology 272:257-66 (2000). PubMed: 10873769