Anti-V2R antibody (ab188748)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-V2R antibody
See all V2R primary antibodies -
Description
Rabbit polyclonal to V2R -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Hamster, Dog, Pig, Chimpanzee, Monkey, Baboon, Gorilla, Common marmoset, Orangutan, Bat
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Immunogen
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Positive control
- Human kidney, renal tubules tissue.
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General notes
This product was previously labelled as AVPR V2
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab188748 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 26 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. -
Tissue specificity
Kidney. -
Involvement in disease
Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI) [MIM:304800]; also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 554 Human
- Entrez Gene: 12000 Mouse
- Entrez Gene: 25108 Rat
- Omim: 300538 Human
- SwissProt: P30518 Human
- SwissProt: O88721 Mouse
- SwissProt: Q00788 Rat
- Unigene: 567240 Human
see all -
Alternative names
- ADHR antibody
- Antidiuretic hormone receptor antibody
- Arginine vasopressin receptor 2 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-V2R antibody (ab188748)Immunohistochemical analysis of Human kidney, renal tubules labeling V2R using ab188748 at 26 μg/ml.
Protocols
References
ab188748 has not yet been referenced specifically in any publications.
