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    v2r-antibody-ab188748.pdf

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Anti-V2R antibody (ab188748)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-V2R antibody (ab188748)

    Key features and details

    • Rabbit polyclonal to V2R
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-V2R antibody
      See all V2R primary antibodies
    • Description

      Rabbit polyclonal to V2R
    • Host species

      Rabbit
    • Specificity

      BLAST analysis of the peptide immunogen showed no homology with other human proteins.
    • Tested Applications & Species

      Application Species
      IHC-P
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide within Human V2R (internal sequence). The exact sequence is proprietary. Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of Human V2R.
      Database link: P30518
      (Peptide available as ab192052)

    • Positive control

      • Human kidney, renal tubules tissue.
    • General notes

       This product was previously labelled as AVPR V2

       

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservative: 0.1% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • More GPCR
      • Neuroscience
      • Neurology process
      • Neuroendocrinology
      • Oxytocin & Vasopressin
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Vasopressin receptor

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Immunizing Peptide (Blocking)

      • Human V2R peptide (ab192052)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab188748 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Human
    All applications
    Mouse
    Rat
    Rabbit
    Horse
    Hamster
    Dog
    Pig
    Chimpanzee
    Monkey
    Baboon
    Gorilla
    Common marmoset
    Orangutan
    Bat
    Application Abreviews Notes
    IHC-P
    Use a concentration of 26 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 26 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Target

    • Function

      Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
    • Tissue specificity

      Kidney.
    • Involvement in disease

      Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
      Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI) [MIM:304800]; also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession P30518 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 554 Human
      • Entrez Gene: 12000 Mouse
      • Entrez Gene: 25108 Rat
      • Omim: 300538 Human
      • SwissProt: P30518 Human
      • SwissProt: O88721 Mouse
      • SwissProt: Q00788 Rat
      • Unigene: 567240 Human
      • Unigene: 383171 Mouse
      • Unigene: 209041 Rat
      see all
    • Alternative names

      • ADHR antibody
      • Antidiuretic hormone receptor antibody
      • Arginine vasopressin receptor 2 antibody
      • AVP R2 antibody
      • AVPR 2 antibody
      • AVPR V2 antibody
      • AVPR2 antibody
      • DI1 antibody
      • DIR 3 antibody
      • DIR antibody
      • DIR3 antibody
      • MGC126533 antibody
      • MGC138386 antibody
      • NDI antibody
      • Nephrogenic diabetes insipidus antibody
      • Renal type arginine vasopressin receptor antibody
      • Renal-type arginine vasopressin receptor antibody
      • V2 receptor antibody
      • V2R antibody
      • V2R_HUMAN antibody
      • Vasopressin V2 antibody
      • Vasopressin V2 receptor antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-V2R antibody (ab188748)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-V2R antibody (ab188748)

      Immunohistochemical analysis of Human kidney, renal tubules labeling V2R using ab188748 at 26 μg/ml.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab188748? Please let us know so that we can cite the reference in this datasheet.

    ab188748 has not yet been referenced specifically in any publications.

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