Overview

  • Product name

  • Description

    Rabbit polyclonal to V2R
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Hamster, Dog, Pig, Chimpanzee, Monkey, Baboon, Gorilla, Common marmoset, Orangutan, Bat
  • Immunogen

    Synthetic peptide within Human V2R (internal sequence). The exact sequence is proprietary. Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of Human V2R.
    Database link: P30518
    (Peptide available as ab192052)

  • Positive control

    • Human kidney, renal tubules tissue.
  • General notes

     This product was previously labelled as AVPR V2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab188748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 26 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • Tissue specificity

    Kidney.
  • Involvement in disease

    Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD) [MIM:300539]. This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis.
    Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI) [MIM:304800]; also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ADHR antibody
    • Antidiuretic hormone receptor antibody
    • Arginine vasopressin receptor 2 antibody
    • AVP R2 antibody
    • AVPR 2 antibody
    • AVPR V2 antibody
    • AVPR2 antibody
    • DI1 antibody
    • DIR 3 antibody
    • DIR antibody
    • DIR3 antibody
    • MGC126533 antibody
    • MGC138386 antibody
    • NDI antibody
    • Nephrogenic diabetes insipidus antibody
    • Renal type arginine vasopressin receptor antibody
    • Renal-type arginine vasopressin receptor antibody
    • V2 receptor antibody
    • V2R antibody
    • V2R_HUMAN antibody
    • Vasopressin V2 antibody
    • Vasopressin V2 receptor antibody
    see all

Images

  • Immunohistochemical analysis of Human kidney, renal tubules labeling V2R using ab188748 at 26 μg/ml.

References

ab188748 has not yet been referenced specifically in any publications.

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