Overview

  • Product name

    Anti-Vaccinia Virus antibody (FITC)
    See all Vaccinia Virus primary antibodies
  • Description

    Rabbit polyclonal to Vaccinia Virus (FITC)
  • Host species

    Rabbit
  • Conjugation

    FITC. Ex: 493nm, Em: 528nm
  • Specificity

    ab156839 does not cross-react with Parainfluenza (1-3), RSV, Adeno, Influenza A&B or HSV1. It is specific for purified virions.
  • Tested applications

    Suitable for: ICC/IF, Indirect ELISAmore details
  • Species reactivity

    Reacts with: Other species, Vaccinia virus
  • Immunogen

    Vaccinia virus - New York City Board of Health (NYCBOH) strain.

  • General notes

    Immunoglobulin concentration is 4-5 mg/ml.

    Covalently coupled with high purity Isomer I of fluorescein isothiocyanate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab156839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/10 - 1/50. Acetone fixation is recommended.
Indirect ELISA 1/1000.

Target

  • Relevance

    Vaccinia virus is an Orthopoxvirus, containing double stranded DNA. Fusion protein plays an important role in the entry of enveloped virus into cells. As vaccinia virus has a wide host range, it is conceivable that certain cellular components that are ubiquitously expressed on the cell mediate virus infection. The study of the entry process, attachment, fusion and the proteins and receptors involved is complex. During vaccinia virus infection, the fusion process is attributed to the action of the 14KDa protein (A27L). The N terminus of this protein recognises heparan sulfate on the cell surface. It interacts with the negative charges of sulfates of glycosaminoglycans (GAGs). Therefore, antibodies that recognize this 14KDa protein are able to neutralize vaccinia virus infection and enable identification other viral and cellular proteins which participate in the vaccinia virus entry process.
  • Alternative names

    • A27L antibody
    • Orthopoxvirus antibody

References

ab156839 has not yet been referenced specifically in any publications.

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