Anti-Vaccinia Virus antibody (FITC) (ab156839)

Overview

  • Product name
    Anti-Vaccinia Virus antibody (FITC)
    See all Vaccinia Virus primary antibodies
  • Description
    Rabbit polyclonal to Vaccinia Virus (FITC)
  • Host species
    Rabbit
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Specificity
    ab156839 does not cross-react with Parainfluenza (1-3), RSV, Adeno, Influenza A&B or HSV1. It is specific for purified virions.
  • Tested applications
    Suitable for: ICC/IF, Indirect ELISAmore details
  • Species reactivity
    Reacts with: Other species, Vaccinia virus
  • Immunogen

    Vaccinia virus - New York City Board of Health (NYCBOH) strain.

  • General notes
    Immunoglobulin concentration is 4-5 mg/ml.

    Covalently coupled with high purity Isomer I of fluorescein isothiocyanate.

Properties

Applications

Our Abpromise guarantee covers the use of ab156839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/10 - 1/50. Acetone fixation is recommended.
Indirect ELISA 1/1000.

Target

  • Relevance
    Vaccinia virus is an Orthopoxvirus, containing double stranded DNA. Fusion protein plays an important role in the entry of enveloped virus into cells. As vaccinia virus has a wide host range, it is conceivable that certain cellular components that are ubiquitously expressed on the cell mediate virus infection. The study of the entry process, attachment, fusion and the proteins and receptors involved is complex. During vaccinia virus infection, the fusion process is attributed to the action of the 14KDa protein (A27L). The N terminus of this protein recognises heparan sulfate on the cell surface. It interacts with the negative charges of sulfates of glycosaminoglycans (GAGs). Therefore, antibodies that recognize this 14KDa protein are able to neutralize vaccinia virus infection and enable identification other viral and cellular proteins which participate in the vaccinia virus entry process.
  • Alternative names
    • A27L antibody
    • Orthopoxvirus antibody

References

ab156839 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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