Key features and details
- Orally available, potent VEGFR2 tyrosine kinase inhibitor
- CAS Number: 443913-73-3
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameVandetanib, VEGFR2 tyrosine kinase inhibitor
DescriptionOrally available, potent VEGFR2 tyrosine kinase inhibitor
- CH 331
Orally available, potent VEGFR2 tyrosine kinase inhibitor (KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Displays anti-angiogenesis activity.
Chemical nameN-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy] quinazolin-4-amine
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 50 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142099 has not yet been referenced specifically in any publications.