Overview

  • Product name

  • Description

    Mouse polyclonal to VANGL1
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length human VANGL1 protein (NP_620409.1).

  • Positive control

    • VANGL1 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab69227 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 70 kDa (predicted molecular weight: 60 kDa).

Target

  • Tissue specificity

    Accordiing to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.
  • Involvement in disease

    Defects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis).
    Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM) [MIM:600145]. SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the Vang family.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ANGL planar cell polarity protein 1 antibody
    • KAI1 C-terminal interacting tetraspanin antibody
    • KITENIN antibody
    • Loop tail protein 2 homolog antibody
    • Loop-tail protein 2 homolog antibody
    • LPP2 antibody
    • MGC5338 antibody
    • STB2 antibody
    • STBM2 antibody
    • Strabismus 2 antibody
    • Strabismus, Drosophila, homolog of, 2 antibody
    • Van Gogh like protein 1 antibody
    • Van Gogh, Drosophila, homolog of, 1 antibody
    • Van Gogh-like protein 1 antibody
    • Vang like 1 (van gogh, Drosophila) antibody
    • Vang like protein 1 antibody
    • Vang-like 1 antibody
    • Vang-like protein 1 antibody
    • VANG1_HUMAN antibody
    • VANGL 1 antibody
    • Vangl1 antibody
    see all

Images

  • All lanes : Anti-VANGL1 antibody (ab69227) at 1/500 dilution

    Lane 1 : VANGL1 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size: 60 kDa
    Observed band size: 70 kDa
    why is the actual band size different from the predicted?

References

ab69227 has not yet been referenced specifically in any publications.

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