Key features and details
- Mouse polyclonal to VANGL1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-VANGL1 antibody
See all VANGL1 primary antibodies
DescriptionMouse polyclonal to VANGL1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Full length human VANGL1 protein (NP_620409.1).
- VANGL1 transfected 293T cell lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab69227 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Detects a band of approximately 70 kDa (predicted molecular weight: 60 kDa).|
Tissue specificityAccordiing to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.
Involvement in diseaseDefects in VANGL1 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis).
Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM) [MIM:600145]. SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant.
Sequence similaritiesBelongs to the Vang family.
- Information by UniProt
- ANGL planar cell polarity protein 1 antibody
- KAI1 C-terminal interacting tetraspanin antibody
- KITENIN antibody
All lanes : Anti-VANGL1 antibody (ab69227) at 1/500 dilution
Lane 1 : VANGL1 transfected 293T lysate
Lane 2 : Non-transfected 293T lysate
Lysates/proteins at 25 µg per lane.
All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Predicted band size: 60 kDa
Observed band size: 70 kDa why is the actual band size different from the predicted?
ab69227 has not yet been referenced specifically in any publications.