Anti-VAP1 antibody [174-5] (ab81718)
Key features and details
- Mouse monoclonal [174-5] to VAP1
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-VAP1 antibody [174-5]
See all VAP1 primary antibodies -
Description
Mouse monoclonal [174-5] to VAP1 -
Host species
Mouse -
Tested applications
Suitable for: IHC-Frmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human VAP1.
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Positive control
- Human tonsil tissue.
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General notes
This antibody inhibits lymphocyte infiltration in liver allograft rejection in rats.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituents: 0.1% BSA, PBS -
Concentration information loading...
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Purification notes
ab81718 is purified and 0.2µM filtered. -
Primary antibody notes
This antibody inhibits lymphocyte infiltration in liver allograft rejection in rats. -
Clonality
Monoclonal -
Clone number
174-5 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab81718 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-Fr |
1/50.
|
Notes |
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IHC-Fr
1/50. |
Target
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Function
Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis. -
Tissue specificity
Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. -
Sequence similarities
Belongs to the copper/topaquinone oxidase family. -
Post-translational
modificationsTopaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N- and O-glycosylated. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 8639 Human
- Omim: 603735 Human
- SwissProt: Q16853 Human
- Unigene: 198241 Human
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Alternative names
- Amine oxidase, copper containing 3 (vascular adhesion protein 1) antibody
- AOC3 antibody
- AOC3_HUMAN antibody
see all
Images
Datasheets and documents
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Datasheet download
References (2)
ab81718 has been referenced in 2 publications.
- Zhang Y et al. Hypoxia serves a key function in the upregulated expression of vascular adhesion protein-1 in vitro and in a rat model of hemorrhagic shock. Mol Med Rep 16:1189-1199 (2017). PubMed: 28627649
- Martelius T et al. Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection. Am J Pathol 165:1993-2001 (2004). PubMed: 15579442