Overview

  • Product name

    VAS 2870, NADPH oxidase inhibitor
  • Description

    NADPH oxidase inhibitor
  • Biological description

    NADPH oxidase inhibitor. Blocks PDGF-mediated NADPH activation and ROS production. Inhibits PMS-induced oxidative burst (IC50 = 2 μM, HeLa cells). Shows anti-ischemic effects ex vivo.
  • Purity

    > 98%
  • CAS Number

    722456-31-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Donoso P  et al. Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium. J Mol Cell Cardiol 68:38-46 (2014). Read more (PubMed: 24417961) »
  • Munnamalai V  et al. Bidirectional interactions between NOX2-type NADPH oxidase and the F-actin cytoskeleton in neuronal growth cones. J Neurochem 130:526-40 (2014). Read more (PubMed: 24702317) »
  • Gonzalez DR  et al. NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 307:H710-21 (2014). Read more (PubMed: 25015966) »

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