Key features and details
- Cell-permeable, potent, selective VEGFR tyrosine kinase inhibitor
- CAS Number: 212141-51-0
- Purity: > 98%
- Soluble in DMSO to 50 mM (with warming) and in ethanol to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product nameVatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor
DescriptionCell-permeable, potent, selective VEGFR tyrosine kinase inhibitor
- 1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate
- CGP 79787
Cell-permeable, potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1) and VEGFR-2 (FLK-1/KDR) (IC50 values are 77 nM and 37 nM respectively). Weaker inhibitor of other tyrosine kinases including PDGFR-β, c-KIT, VEGFR-3 (FLT-4) and c-FMS (IC50 values are 580 nM, 730 nM, 660 nM and 1.4 μM respectively). Inactive against EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 μM). Induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model.
Chemical nameN-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 50 mM (with warming) and in ethanol to 10 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142199 has been referenced in 1 publication.
- Zhang X et al. Metabolomics for Biomarker Discovery in Fermented Black Garlic and Potential Bioprotective Responses against Cardiovascular Diseases. J Agric Food Chem 67:12191-12198 (2019). PubMed: 31588747