Overview

  • Product name

  • Description

    Rabbit polyclonal to VAV1
  • Host species

    Rabbit
  • Specificity

    This antibody detects endogenous levels of total VAV1 protein.
  • Tested applications

    Suitable for: ELISA, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    A synthesized non-phosphopeptide derived from human VAV1 around the phosphorylation site of tyrosine 160

  • Positive control

    • Hela cells

Properties

Applications

Our Abpromise guarantee covers the use of ab62622 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/5000.
ICC/IF 1/500 - 1/1000.

Target

  • Function

    Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
  • Tissue specificity

    Widely expressed in hematopoietic cells but not in other cell types.
  • Sequence similarities

    Contains 1 CH (calponin-homology) domain.
    Contains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 SH2 domain.
    Contains 2 SH3 domains.
  • Domain

    The DH domain is involved in interaction with CCPG1.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues.
  • Information by UniProt
  • Database links

  • Alternative names

    • Oncogene vav antibody
    • p95Vav antibody
    • Proto-oncogene vav antibody
    • Protooncogene vav antibody
    • VAV 1 antibody
    • VAV 1 oncogene antibody
    • VAV antibody
    • Vav proto oncogene antibody
    • VAV_HUMAN antibody
    • VAV1 antibody
    see all

Images

  • Immunofluorescence analysis of HeLa cells, using ab62622 at a 1:500 dilution.

    Left image untreated.

    Right image treated with peptide.

References

ab62622 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab62622.
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