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Our customer would like to use ab14734 for IHC-P, staining of human cancer sections (from different origins) and healthy human sections. Kindly advise if this specific antibody (ab14734) will help to distinguish between healthy and cancer tissue? In addition to that, please explain the difference between Anti-VDAC1 / Porin antibodies with the addition of "Mitochondrial Loading Control" after the name of the antibody (like ab14734) and Anti-VDAC1 / Porin antibodies that lack this description (ab34726, for ex). Thanks in advance for your assistance.
Asked on Nov 04 2011
Thank you for your inquiry. VDAC1 is a mitochondrial protein and I believe its level of expression is pretty ubiquitous in all tissues, cancerous and normal. According to the Human Protein Atlas, VDAC1 is expressed in most normal and cancer tissues tested. http://www.proteinatlas.org/ENSG00000213585/normal http://www.proteinatlas.org/ENSG00000213585/cancer All anti-VDAC1/Porin antibodies in our catalogue will stain the same mitochondrial protein. The ones named "Mitochondrial Loading Control" have typically been cited in papers to have been used as such. That is really the only main difference in the name. I hope this information helps. Please contact us with any other questions.
Answered on Nov 04 2011