Overview

  • Product name

  • Description

    Rabbit polyclonal to VDAC2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-189 of Human VDAC2 (UniProt ID: P45880).

  • Positive control

    • A549 HeLa cell lysate; HepG2 and HCT116 whole cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab126120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 32 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with 10mM Citrate buffer (PH6.0) or Tris-EDTA buffer ( PH8.0)).

Target

  • Function

    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
  • Tissue specificity

    Expressed in all tissues examined.
  • Sequence similarities

    Belongs to the eukaryotic mitochondrial porin family.
  • Domain

    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
  • Cellular localization

    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • B-36 vdac antibody
    • FLJ23841 antibody
    • hVDAC2 antibody
    • OTTHUMP00000019878 antibody
    • OTTHUMP00000019879 antibody
    • OTTHUMP00000019880 antibody
    • Outer mitochondrial membrane protein porin 2 antibody
    • POR antibody
    • Porin-2 antibody
    • VDAC 2 antibody
    • VDAC-2 antibody
    • VDAC2 antibody
    • VDAC2_HUMAN antibody
    • Vdac6 antibody
    • Voltage dependent anion channel 2 antibody
    • Voltage dependent anion selective channel protein 2 antibody
    • Voltage-dependent anion-selective channel protein 2 antibody
    see all

Images

  • All lanes : Anti-VDAC2 antibody (ab126120) at 1/1000 dilution

    Lane 1 : HepG2 whole cel lysate
    Lane 2 : HCT116 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 32 kDa



    12% SDS PAGE
  • ab126120, at 1/250 dilution, staining VDAC2 in paraffin embedded Human colon carcinoma tissue by Immunohistochemistry.

References

This product has been referenced in:

  • Aono Y  et al. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun 505:1203-1210 (2018). Read more (PubMed: 30327144) »
  • Zhou K  et al. VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells. Cell Death Dis 9:988 (2018). Read more (PubMed: 30250190) »
See all 2 Publications for this product

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