Key features and details
- Potent, selective ATP competitive ATR inhibitor
- CAS Number: 1232410-49-9
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameVE-821, ATP competitive ATR inhibitor
DescriptionPotent, selective ATP competitive ATR inhibitor
- ATR Inhibitor IV
- VE 821
Potent, selective ATP competitive ATR inhibitor (Ki = 13 nM). Exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro. Decreases phosphorylation of Chk1 and increases sensitivity of pancreatic cancer cells and leukemia cells to radiation.
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Epigenetics and Nuclear Signaling
- DNA / RNA
- DNA Damage & Repair
- DNA Damage Response
- DNA Damage Recognition
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab219506 has not yet been referenced specifically in any publications.