VE-821, ATP competitive ATR inhibitor (ab219506)

Overview

  • Product name

    VE-821, ATP competitive ATR inhibitor
  • Description

    Potent, selective ATP competitive ATR inhibitor
  • Alternative names

    • ATR Inhibitor IV
    • VE 821
    • VE821
  • Biological description

    Potent, selective ATP competitive ATR inhibitor (Ki = 13 nM). Exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro. Decreases phosphorylation of Chk1 and increases sensitivity of pancreatic cancer cells and leukemia cells to radiation.

  • Purity

    > 98%
  • CAS Number

    1232410-49-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
  • Molecular weight

    368.41
  • Molecular formula

    C18H16N4O3S
  • PubChem identifier

    51000408
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Flynn RL  et al. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science 347:273-7 (2015). Read more (PubMed: 25593184) »
  • Vávrová J  et al. Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60). Radiat Environ Biophys 52:471-9 (2013). Read more (PubMed: 23934411) »
  • Prevo R  et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther 13:1072-81 (2012). Read more (PubMed: 22825331) »
  • Reaper PM  et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol 7:428-30 (2011). Read more (PubMed: 21490603) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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