Key features and details
- Rat monoclonal [BV13] to VE Cadherin - Intercellular Junction Marker
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
Product nameAnti-VE Cadherin antibody [BV13] - Intercellular Junction Marker
See all VE Cadherin primary antibodies
DescriptionRat monoclonal [BV13] to VE Cadherin - Intercellular Junction Marker
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Mouse
Recombinant fragment corresponding to the extracellular domain of Mouse VE Cadherin.
- bEnd.3 cells
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab91064 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use 1µg for 106 cells.
Use 1µg for 106 cells in 100 µl total staining volume.
ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionCadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
Tissue specificityEndothelial tissues and brain.
Sequence similaritiesContains 5 cadherin domains.
modificationsPhosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.
Cellular localizationCell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.
- Information by UniProt
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ab91064 has been referenced in 4 publications.
- Molinari F et al. The mitochondrial metabolic reprogramming agent trimetazidine as an 'exercise mimetic' in cachectic C26-bearing mice. J Cachexia Sarcopenia Muscle 8:954-973 (2017). PubMed: 29130633
- Giampietro C et al. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol 211:1177-92 (2015). PubMed: 26668327
- Herzog BH et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502:105-9 (2013). PubMed: 23995678
- Broermann A et al. Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J Exp Med 208:2393-401 (2011). WB, ICC/IF ; Mouse . PubMed: 22025303