Key features and details
- Mouse monoclonal [122.2] to VE-PTP
- Suitable for: WB, ICC/IF, ICC, IP
- Reacts with: Rat
- Isotype: IgM
Product nameAnti-VE-PTP antibody [122.2]
See all VE-PTP primary antibodies
DescriptionMouse monoclonal [122.2] to VE-PTP
SpecificityThis antibody is specific for Receptor Tyrosine Phosphatase Beta (phosphacan).
Tested applicationsSuitable for: WB, ICC/IF, ICC, IPmore details
Species reactivityReacts with: Rat
Tissue, cells or virus corresponding to Rat VE-PTP. (Embryonic rat brain proteoglycans).
Protein previously labeled as PTPRB.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferConstituent: PBS
Concentration information loading...
Purification notesConcentrated antibody. This antibody was grown in protein free medium, then concentrated snd dialysed against PBS.
Our Abpromise guarantee covers the use of ab31654 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/100 - 1/2500. Predicted molecular weight: 224 kDa.|
|ICC/IF||Use at an assay dependent dilution.|
|ICC||Use at an assay dependent dilution.|
|IP||Use at an assay dependent dilution.|
FunctionPlays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Contains 17 fibronectin type-III domains.
Contains 1 tyrosine-protein phosphatase domain.
- Information by UniProt
- HPTP BETA antibody
- HPTPB antibody
- Phosphacan receptor type B antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab31654 has not yet been referenced specifically in any publications.