Overview

  • Product name

  • Description

    Rabbit polyclonal to VE-PTP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Recombinant fragment (His-tag) corresponding to Rat VE-PTP aa 1041-1310. (Expressed in E.coli).

  • Positive control

    • WB: Recombinant rat VE-PTP protein; Rat liver lysate. IHC-P: Rat cerebrum, liver, spinal cord, heart and skeletal muscle tissues.
  • General notes

    Protein previously labeled as PTPRB.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab231670 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab231670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 20 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 224 kDa.

Target

  • Function

    Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
    Contains 17 fibronectin type-III domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Alternative names

    • HPTP BETA antibody
    • HPTPB antibody
    • Phosphacan receptor type B antibody
    • Protein tyrosine phosphatase receptor type B antibody
    • Protein-tyrosine phosphatase beta antibody
    • PTPB antibody
    • Ptprb antibody
    • PTPRB_HUMAN antibody
    • R PTP BETA antibody
    • R-PTP-beta antibody
    • Receptor-type tyrosine-protein phosphatase beta antibody
    • RPTPB antibody
    • Vascular endothelial protein tyrosine phosphatase antibody
    • VE-PTP antibody
    see all

Images

  • Anti-VE-PTP antibody (ab231670) at 2 µg/ml + Recombiant rat VE-PTP protein

    Secondary
    HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

    Predicted band size: 224 kDa

  • Anti-VE-PTP antibody (ab231670) at 2 µg/ml + Rat liver lysate

    Secondary
    HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution

    Predicted band size: 224 kDa

  • Paraffin-embedded rat brain tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

  • Paraffin-embedded rat liver tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

  • Paraffin-embedded rat spinal cord tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

  • Paraffin-embedded rat heart tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

  • Paraffin-embedded rat skeletal muscle tissue stained for VE-PTP using ab231670 at 20 μg/ml in immunohistochemical analysis. DAB staining.

References

ab231670 has not yet been referenced specifically in any publications.

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