Key features and details
- Competitive nicotinic acetylcholine receptor (nAChR) antagonist
- CAS Number: 50700-72-6
- Soluble in DMSO to 100 mM, in ethanol to 100 mM and in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameVecuronium bromide, Competitive nicotinic acetylcholine receptor antagonist
DescriptionCompetitive nicotinic acetylcholine receptor (nAChR) antagonist
Competitive nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 9.9 nM). Muscle relaxant. Inhibits neural response to hypoxia.
Chemical name1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM, in ethanol to 100 mM and in water to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120536 has been referenced in 4 publications.
- Pei Y et al. Excitotoxicity and compensatory upregulation of GAD67 in fetal rat hippocampus caused by prenatal nicotine exposure are associated with inhibition of the BDNF pathway. Food Chem Toxicol 123:314-325 (2019). PubMed: 30389584
- Fan G et al. Decreased levels of H3K9ac and H3K27ac in the promotor region of ovarian P450 aromatase mediated low estradiol synthesis in female offspring rats induced by prenatal nicotine exposure as well as in human granulosa cells after nicotine treatment. Food Chem Toxicol 128:256-266 (2019). PubMed: 30959089
- Zhou J et al. nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11ß-HSD2. Toxicol Appl Pharmacol 344:1-12 (2018). PubMed: 29486207
- Zhang G et al. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicol Lett 296:31-38 (2018). PubMed: 30036686