Anti-VEGF Receptor 1 antibody [EWF] (ab11934)

Submit a review Submit a question References (1)

Overview

  • Product name

    Anti-VEGF Receptor 1 antibody [EWF]
    See all VEGF Receptor 1 primary antibodies

  • Description

    Mouse monoclonal [EWF] to VEGF Receptor 1

  • Host species

    Mouse

  • Tested applications

    Suitable for: Flow Cyt, ELISA, WBmore details

  • Species reactivity

    Reacts with: Mouse, Human

  • Immunogen

    Recombinant full length protein corresponding to Human VEGF Receptor 1 aa 1-687.
    Sequence:

    MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLH LQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQAN HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE GRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK EIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVL NCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK RSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA GNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGN RIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISF YITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK KEITIRGEHCNKKAVFSRISKFKSTRNDCTTQSNVKH


    Database link: P17948-2

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • WB: Recombinant human soluble VEGF Receptor 1; Conditioned media from insect cells expressing recombinant human soluble VEGF Receptor 1; Supernantant from Adenovirus Infected A549 cells expressing mouse VEGF Receptor 1.

Properties

Applications

Our Abpromise guarantee covers the use of ab11934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use a concentration of 2 - 10 µg/ml.
ELISA Use a concentration of 1 - 10 µg/ml.
WB Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 150 kDa.

Target

  • Function

    Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.

  • Tissue specificity

    Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform sFlt1 is strongly expressed in placenta.

  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • EC 2.7.10.1 antibody
      • FLT 1 antibody
      • FLT antibody
      • Flt-1 antibody
      • FLT1 antibody
      • Fms like tyrosine kinase 1 antibody
      • Fms related tyrosine kinase 1 antibody
      • Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody
      • Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor antibody
      • Fms-like tyrosine kinase 1 antibody
      • FRT antibody
      • Soluble VEGF receptor 1 14 antibody
      • Soluble VEGFR1 variant 2 antibody
      • Soluble VEGFR1 variant 21 antibody
      • Tyrosine protein kinase FRT antibody
      • Tyrosine protein kinase receptor FLT antibody
      • Tyrosine-protein kinase FRT antibody
      • Tyrosine-protein kinase receptor FLT antibody
      • Vascular endothelial growth factor receptor 1 antibody
      • Vascular endothelial growth factor vascular permeability factor receptor antibody
      • Vascular permeability factor receptor 1 antibody
      • Vascular permeability factor receptor antibody
      • VEGFR 1 antibody
      • VEGFR-1 antibody
      • VEGFR1 antibody
      • VGFR1_HUMAN antibody
      see all

    Images

    • Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)
      Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)
      Lane 1 : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 mg/ml
      Lane 2 : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 µg/ml

      Lane 1 : Recombinant human soluble VEGF Receptor 1
      Lane 2 : Supernantant from Adenovirus Infected A549 cells expressing mouse VEGF Receptor 1

      Predicted band size: 150 kDa

    • Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)
      Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)
      All lanes : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 µg/ml

      All lanes : Conditioned media from insect cells expressing recombinant human
      soluble VEGF Receptor 1

      Predicted band size: 150 kDa

    • Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)
      Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)
      All lanes : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 µg/ml

      All lanes : Conditioned media from insect cells expressing recombinant human
      soluble VEGF Receptor 1

      Predicted band size: 150 kDa

    References

    This product has been referenced in:

    • Farzaneh Behelgardi M  et al. A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis. Sci Rep 8:17924 (2018). Read more (PubMed: 30560942) »
    See 1 Publication for this product

    Publishing research using ab11934? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    There are currently no Customer reviews or Questions for ab11934.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com