Anti-VEGF Receptor 2 antibody [3D09] (ab42230)
Key features and details
- Rat monoclonal [3D09] to VEGF Receptor 2
- Suitable for: Functional Studies
- Reacts with: Mouse
- Isotype: IgG2a
Overview
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Product name
Anti-VEGF Receptor 2 antibody [3D09]
See all VEGF Receptor 2 primary antibodies -
Description
Rat monoclonal [3D09] to VEGF Receptor 2 -
Host species
Rat -
Specificity
This antibody shows no cross-reactivity with VEGF Receptor 1. -
Tested applications
Suitable for: Functional Studiesmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Purified fragment, corresponding to N terminal amino acids 30-200 of Mouse VEGF Receptor 2
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Positive control
- Mouse skin endothelial cells (mSENDs)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
3D09 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab42230 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Functional Studies |
Use a concentration of 1 - 5 µg/ml. Can induce VEGF Receptor 2 tyrosine phosphorylation in mouse skin endothelial cells.
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Notes |
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Functional Studies
Use a concentration of 1 - 5 µg/ml. Can induce VEGF Receptor 2 tyrosine phosphorylation in mouse skin endothelial cells. |
Target
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Function
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. -
Involvement in disease
Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. -
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
Post-translational
modificationsPhosphorylated. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 16542 Mouse
- SwissProt: P35918 Mouse
- Unigene: 285 Mouse
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Alternative names
- CD309 antibody
- CD309 antigen antibody
- EC 2.7.10.1 antibody
see all
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (1)
ab42230 has been referenced in 1 publication.
- Yu CQ et al. Vascular endothelial growth factor mediates corneal nerve repair. Invest Ophthalmol Vis Sci 49:3870-8 (2008). PubMed: 18487369