Recombinant
RabMAb

Recombinant Anti-VEGF Receptor 3 antibody [EPR22293-58] - BSA and Azide free (ab243558)

Overview

  • Product name
    Anti-VEGF Receptor 3 antibody [EPR22293-58] - BSA and Azide free
    See all VEGF Receptor 3 primary antibodies
  • Description
    Rabbit monoclonal [EPR22293-58] to VEGF Receptor 3 - BSA and Azide free
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Flow Cytmore details
    Unsuitable for: ICC/IF,IHC-P or WB
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human VEGF Receptor 3 aa 1-750. The exact sequence is proprietary.
    Database link: P35916

  • Positive control
    • Flow cyt: HEL cells.
  • General notes

    The formulation and the concentration of this product is compatible for metal-conjugation for mass cytometry (CyTOF®).

    ab243558 is a PBS-only buffer format of ab243233. Please refer to ab243233 for recommended dilutions, protocols, and image data.

    Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab243558 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.
  • Application notes
    Is unsuitable for ICC/IF,IHC-P or WB.
  • Target

    • Function
      Receptor for VEGFC. Has a tyrosine-protein kinase activity.
    • Tissue specificity
      Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.
    • Involvement in disease
      Defects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
      Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.
    • Sequence similarities
      Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
      Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 protein kinase domain.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • EC 2.7.10.1 antibody
      • flt 4 antibody
      • FLT-4 antibody
      • FLT4 antibody
      • FLT41 antibody
      • Fms related tyrosine kinase 4 antibody
      • Fms-like tyrosine kinase 4 antibody
      • LMPH1A antibody
      • PCL antibody
      • Soluble VEGFR3 variant 1 antibody
      • Soluble VEGFR3 variant 2 antibody
      • Soluble VEGFR3 variant 3 antibody
      • Tyrosine protein kinase receptor FLT4 antibody
      • Tyrosine-protein kinase receptor FLT4 antibody
      • Vascular endothelial growth factor receptor 3 antibody
      • Vascular endothelial growth factor receptor 3 precursor antibody
      • VEGF R3 antibody
      • VEGFR 3 antibody
      • VEGFR-3 antibody
      • VEGFR3 antibody
      • VGFR3_HUMAN antibody
      see all

    Images

    • Flow cytometric analysis of MCF7 (human breast adenocarcinoma cell line) (Left panel) and HEL (human bone marrow erythroleukemia cell line) (Right panel)cell lines labeling VEGF Receptor 3 with ab243233 at 1/500 (red) compared with Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730) (black) and an unlabeled control (cells without incubation with primary antibody and secondary antibody) (blue). Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)), at 1/2000 dilution was used as the secondary antibody.

      Gated on viable cells.

      Negative control: MCF7 (PMID: 18538738).

      This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab243233).

    References

    ab243558 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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