Anti-VEGFC antibody [9/E7] (ab106512)
Key features and details
- Mouse monoclonal [9/E7] to VEGFC
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Rat, Human
- Isotype: IgG2a
Overview
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Product name
Anti-VEGFC antibody [9/E7]
See all VEGFC primary antibodies -
Description
Mouse monoclonal [9/E7] to VEGFC -
Host species
Mouse -
Tested applications
Suitable for: IHC-P, IHC-Frmore details -
Species reactivity
Reacts with: Rat, Human -
Immunogen
Recombinant fragment (His-tag) corresponding to Human VEGFC aa 103-215.
Database link: P49767 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
9/E7 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106512 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 2 - 10 µg/ml.
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IHC-Fr |
Use a concentration of 2 - 10 µg/ml.
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Notes |
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IHC-P
Use a concentration of 2 - 10 µg/ml. |
IHC-Fr
Use a concentration of 2 - 10 µg/ml. |
Target
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Function
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. -
Tissue specificity
Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. -
Sequence similarities
Belongs to the PDGF/VEGF growth factor family. -
Post-translational
modificationsUndergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 7424 Human
- Entrez Gene: 114111 Rat
- Omim: 601528 Human
- SwissProt: P49767 Human
- SwissProt: Q6FH59 Human
- SwissProt: O35757 Rat
- Unigene: 435215 Human
- Unigene: 6913 Rat
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Alternative names
- Flt 4L antibody
- Flt4 ligand antibody
- FLT4 ligand DHM antibody
see all
Images
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Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.
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Immunohistochemistry (Frozen sections) analysis of rat mammary tumor tissue sections labelling VEGFC with ab106512.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue sections labelling VEGFC with ab106512.
Datasheets and documents
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Datasheet download
References (3)
ab106512 has been referenced in 3 publications.
- Kusumoto S et al. An immature inhibin-a-expressing subpopulation of ovarian clear cell carcinoma cells is related to an unfavorable prognosis. Cancer Med 10:1485-1500 (2021). PubMed: 33611864
- Liu X et al. Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels. Acta Neuropathol Commun 8:16 (2020). PubMed: 32059751
- Loessner D et al. A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns. Biomaterials 190-191:63-75 (2019). PubMed: 30396040