VEGFR2 Kinase Inhibitor I, receptor tyrosine kinase (RTK) inhibitor (ab145888)

Overview

  • Product name

    VEGFR2 Kinase Inhibitor I, receptor tyrosine kinase (RTK) inhibitor
  • Description

    Highly selective, cell-permeable indolin-2-one class receptor tyrosine kinase (RTK) inhibitor for vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1).
  • Alternative names

    • 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid, ethyl ester
    • IN1018
    • SU 5408
    • VEGF Receptor 2 Kinase Inhibitor I
  • Biological description

    Highly selective, cell-permeable inhibitor of VEGFR2 kinase. Little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor.

  • Purity

    > 95%
  • CAS Number

    15966-93-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (Z)-3-[[2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl]methylidenyl]indolin-2-one
  • Molecular weight

    310.40
  • Molecular formula

    C18H18N2O3
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Sun L  et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem 41:2588-603 (1998). Read more (PubMed: 9651163) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145888.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up