Key features and details
- Na+ channel opener
- CAS Number: 71-62-5
- Soluble in ethanol to 100 mM
- Form / State: Solid
- Source: Liliaceae sp.
Product nameVeratridine, Na+ channel opener
DescriptionNa+ channel opener
Biological descriptionAlkaloid toxin found in Liliaceae plants. Causes persistent opening of the voltage-gated Na+ channel and reduces its single-channel conductance. Channel opener.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120279 has been referenced in 5 publications.
- Mohammed ZA et al. An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery. Pain 161:1100-1108 (2020). PubMed: 31929383
- Mohammed ZA et al. Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep 7:45221 (2017). PubMed: 28338073
- Sousa SR et al. Discovery and mode of action of a novel analgesic ß-toxin from the African spider Ceratogyrus darlingi. PLoS One 12:e0182848 (2017). PubMed: 28880874
- Henriques ST et al. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. J Biol Chem 291:17049-65 (2016). PubMed: 27311819
- Zimmermann K et al. Analgesic treatment of ciguatoxin-induced cold allodynia. Pain 154:1999-2006 (2013). PubMed: 23778293