Veratridine, Na+ channel opener (ab120279)
Key features and details
- Na+ channel opener
- CAS Number: 71-62-5
- Soluble in ethanol to 100 mM
- Form / State: Solid
- Source: Liliaceae sp.
Overview
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Product name
Veratridine, Na+ channel opener -
Description
Na+ channel opener -
Biological description
Alkaloid toxin found in Liliaceae plants. Causes persistent opening of the voltage-gated Na+ channel and reduces its single-channel conductance. Channel opener. -
CAS Number
71-62-5 -
Chemical structure
Properties
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Chemical name
3-Veratroylveracevine -
Molecular weight
673.80 -
Molecular formula
C36H51NO11 -
PubChem identifier
6610253 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1ccc(cc1OC)C(=O)OC4CC[C@@]7(C)C5CCC6[C@]8(O)C[C@H](O)[C@@]3(O)C(CN2CC(C)CCC2[C@@]3(C)O)[C@]8(O)C[C@@]67O[C@]45O -
Source
Liliaceae sp.
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Research areas
Images
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Chemical Structure - Veratridine, Na+ channel opener (ab120279)2D chemical structure image of ab120279, Veratridine, Na+ channel opener
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab120279 has been referenced in 5 publications.
- Mohammed ZA et al. An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery. Pain 161:1100-1108 (2020). PubMed: 31929383
- Mohammed ZA et al. Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep 7:45221 (2017). PubMed: 28338073
- Sousa SR et al. Discovery and mode of action of a novel analgesic ß-toxin from the African spider Ceratogyrus darlingi. PLoS One 12:e0182848 (2017). PubMed: 28880874
- Henriques ST et al. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. J Biol Chem 291:17049-65 (2016). PubMed: 27311819
- Zimmermann K et al. Analgesic treatment of ciguatoxin-induced cold allodynia. Pain 154:1999-2006 (2013). PubMed: 23778293