Verteporfin (Visudyne), Benzoporphyrin derivative (ab143294)

Overview

  • Product name

    Verteporfin (Visudyne), Benzoporphyrin derivative
  • Description

    Benzoporphyrin derivative. Antiangiogenic agent.
  • Biological description

    Benzoporphyrin derivative. Antiangiogenic agent. Produces ROS on stimulation with nonthermal red light in the presence of oxygen. Prevents corneal neovascularization and shows antitumor effects in vivo.
  • Purity

    > 97%
  • CAS Number

    129497-78-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4S,4aR)-rel-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
  • Molecular weight

    718.79
  • Molecular formula

    C41H42N4O8
  • PubChem identifier

    5362420
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mg/ml
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C2=CC3=NC(=CC4=C(C(=C(N4)C=C5[C@@]6([C@@H](C(=CC=C6C(=N5)C=C1N2)C(=O)OC)C(=O)OC)C)C)CCC(=O)OC)C(=C3C)CCC(=O)O)C=C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ammar DA & Kahook MY In vitro effects of verteporfin on ocular cells. Mol Vis 19:424-9 (2013). Read more (PubMed: 23441114) »
  • Tong ZS  et al. Enhanced antitumor effects of BPD-MA-mediated photodynamic therapy combined with adriamycin on breast cancer in mice. Acta Pharmacol Sin 33:1319-24 (2012). Read more (PubMed: 22842729) »
  • Abdelkawi SA & Hassan AA Evaluation of protein change and oxidative stress index after photodynamic therapy of corneal neovascularization. Gen Physiol Biophys 31:449-55 (2012). Read more (PubMed: 23255672) »

Customer reviews and Q&As

Question
Answer

ab143294 can be solubilized in DMSO, in which it has a solubility at 25C of 100 mg/ml.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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