Overview

  • Product name

    VGX-1027 (Git-27), TLR4 inhibitior
  • Description

    Immunomodulatory agent. TLR4 inhibitior.
  • Alternative names

    • Git-27
  • Biological description

    Immunomodulatory agent. TLR4 inhibitor. TLR4 and TLR 2/6 signaling pathway modulator. Inhibits inflammatory antigen presentation. Inhibits IL1-β, IL-10, IFN-γ and TNF-α secretion. Shows anti-inflammatory effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    6501-72-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Laird MD  et al. High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4. Glia 62:26-38 (2014). Read more (PubMed: 24166800) »
  • Fagone P  et al. VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus. Immunology 142:594-602 (2014). Read more (PubMed: 24527796) »
  • Mangano K  et al. Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats. Br J Pharmacol 155:722-30 (2008). Read more (PubMed: 18776919) »

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