VH298, VHL inhibitor (ab230370)
Key features and details
- Potent, cell permeable VHL inhibitor
- Purity: > 98%
100 mM in DMSO
100mM in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VH298, VHL inhibitor -
Description
Potent, cell permeable VHL inhibitor -
Biological description
VH298 is a cell permeable compound that binds tightly to VHL (KD = 80- 90 nM in in vitro binding assays) leading to cellular accumulation of HIF1-α. VH298 selectively stabilizes hydroxylated HIF1-α and induces HIF-dependent transcription.
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Purity
> 98% -
Chemical structure
Properties
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Chemical name
(2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
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Molecular weight
523.65 -
Molecular formula
C27H33N5O4S -
PubChem identifier
122199236 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
100 mM in DMSO
100mM in ethanol
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SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab230370 has been referenced in 1 publication.
- Wang Y et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell 179:1144-1159.e15 (2019). PubMed: 31708126