Overview

  • Product name

    Vidarabine (Vira-A), Adenosine analog
  • Description

    Antiviral agent. Adenosine analog.
  • Biological description

    Antiviral agent (IC50 = 21 μM for HSV-1). Adenosine analog. Inhibits viral DNA synthesis. Inhibits adenylyl cyclase. Blood-brain barrier permeable. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    5536-17-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3S,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • Molecular weight

    267.24
  • Molecular formula

    C10H13N5O4
  • PubChem identifier

    21704
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 100 mM (with warming). Soluble in HCl to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CO)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Braeunig JH  et al. Similarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout mice. PLoS One 8:e68009 (2013). Read more (PubMed: 23840883) »
  • De Lorenzo MS  et al. 'Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption' Aging Cell : (2013). Read more (PubMed: 23957304) »
  • Wang LX  et al. Characterization of DNA polymerase-associated acyclovir-resistant herpes simplex virus type 1: mutations, sensitivity to antiviral compounds, neurovirulence, and in-vivo sensitivity to treatment. Jpn J Infect Dis 66:404-10 (2013). Read more (PubMed: 24047739) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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