Overview

  • Product name

    Vinblastine sulfate, Microtubule dynamics inhibitor
  • Description

    Potent microtubule dynamics inhibitor
  • Biological description

    Potent microtubule dynamics inhibitor. Inhibits tubulin addition (Ki = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC50 = 1 nM). Antitumor effects in vivo.
  • Purity

    > 95%
  • CAS Number

    143-67-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Rai A  et al. An antitubulin agent BCFMT inhibits proliferation of cancer cells and induces cell death by inhibiting microtubule dynamics. PLoS One 7:e44311 (2012). Read more (PubMed: 22952952) »
  • Dhamodharan R  et al. Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell 6:1215-29 (1995). Read more (PubMed: 8534917) »
  • Jordan MA  et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res 45:2741-7 (1985). Read more (PubMed: 3986806) »
  • El-Galley R  et al. Camptothecin analogues and vinblastine in the treatment of renal cell carcinoma: an in vivo study using a human orthotopic renal cancer xenograft. Urol Oncol 21:49-57 (0). Read more (PubMed: 12684128) »

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