Overview

  • Product name

    Vindoline, H+/K+ ATPase inhibitor
  • Description

    Weak tubulin polymerization inhibitor. H+/K+ ATPase inhibitor.
  • Biological description

    Weak tubulin polymerization inhibitor. H+/K+ ATPase inhibitor (IC50 = 846 μM). Precursor molecule of vinblastine (ab141475) and vincristine (ab120226). Weakly affects bipolar mitotic spindle formation. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    2182-14-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sertel S  et al. Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol 81:723-35 (2011). Read more (PubMed: 21219884) »
  • Freitas CS  et al. Inhibition of gastric H+, K(+)-ATPase activity by compounds from medicinal plants. Nat Prod Commun 6:1253-4 (2011). Read more (PubMed: 21941891) »
  • Passarella D  et al. Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Bioorg Med Chem 16:6269-85 (2008). Read more (PubMed: 18468444) »
  • Prakash V & Timasheff SN Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry 30:873-80 (1991). Read more (PubMed: 1988072) »

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