Overview

  • Product name

    Vinorelbine, cell proliferation inhibitor
  • Description

    Potent and selective cell proliferation inhibitor
  • Biological description

    Potent and selective cell proliferation inhibitor (IC50 = 1.25 nM). Vinca alkaloid. Suppresses rate and extent of mitotic microtubule growing events. Antimitotic and anticancer agent. Active in vivo and in vitro.
  • Purity

    > 90%
  • CAS Number

    71486-22-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(Acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl aspidospermidine-3-carboxylic acid methyl ester
  • Molecular weight

    778.93
  • Molecular formula

    C45H54N4O8
  • PubChem identifier

    5672
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hu Y  et al. Antitumor efficacy of oblimersen Bcl-2 antisense oligonucleotide alone and in combination with vinorelbine in xenograft models of human non-small cell lung cancer. Clin Cancer Res 10:7662-70 (2004). Read more (PubMed: 15569999) »
  • Liu XM  et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer 89:1566-73 (2003). Read more (PubMed: 14562033) »
  • Ngan VK  et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol 60:225-32 (2001). Read more (PubMed: 11408618) »

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