Overview

  • Product name

    Vinpocetine, PDE1 inhibitor
  • Description

    Cell-permeable PDE1 inhibitor
  • Biological description

    Cell-permeable PDE1 inhibitor (Ki = 14 μM). Neuroprotective, vasodilator and nootropic agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    42971-09-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
  • Molecular weight

    350.45
  • Molecular formula

    C22H26N2O2
  • PubChem identifier

    443955
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 10 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Muravyov A & Tikhomirova I Role Ca(2+) in mechanisms of the red blood cells microrheological changes. Adv Exp Med Biol 740:1017-38 (2012). Read more (PubMed: 22453982) »
  • Manallack DT  et al. The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem 48:3449-62 (2005). Read more (PubMed: 15887951) »
  • Ahn HS  et al. Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta. Biochem Pharmacol 38:3331-9 (1989). Read more (PubMed: 2554921) »

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