Product nameAnti-Viperin antibody [MaP.VIP]
See all Viperin primary antibodies
DescriptionMouse monoclonal [MaP.VIP] to Viperin
Tested applicationsSuitable for: WB, Flow Cyt, ICC/IF, IPmore details
Unsuitable for: IHC-Fr
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab107359 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 42 kDa. The typical starting working dilution is 1:50.|
|Flow Cyt||Use at an assay dependent concentration.
The typical starting working dilution is 1:50.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
|ICC/IF||Use at an assay dependent concentration.|
|IP||Use at an assay dependent concentration.|
FunctionInvolved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus.
Sequence similaritiesBelongs to the RSAD2 family.
Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus. Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28.
- Information by UniProt
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This product has been referenced in:
- Lindqvist R et al. Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin. J Neuroinflammation 15:80 (2018). WB ; Mouse . Read more (PubMed: 29544502) »
- Upadhyay AS et al. Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. J Biol Chem 292:13879-13889 (2017). Read more (PubMed: 28615450) »