Key features and details
- Mouse monoclonal [MaP.VIP] to Viperin
- Reacts with: Mouse, Human
- Isotype: IgG2a
Product nameAnti-Viperin antibody [MaP.VIP]
See all Viperin primary antibodies
DescriptionMouse monoclonal [MaP.VIP] to Viperin
Species reactivityReacts with: Mouse, Human
Predicted to work with: Rat
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Concentration information loading...
PurityProtein G purified
FunctionInvolved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus.
Sequence similaritiesBelongs to the RSAD2 family.
Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus. Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28.
- Information by UniProt
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To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab107359 has been referenced in 4 publications.
- Lindqvist R et al. Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin. J Neuroinflammation 15:80 (2018). WB ; Mouse . PubMed: 29544502
- Upadhyay AS et al. Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. J Biol Chem 292:13879-13889 (2017). PubMed: 28615450
- Van der Hoek KH et al. Viperin is an important host restriction factor in control of Zika virus infection. Sci Rep 7:4475 (2017). PubMed: 28667332
- Tang HB et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep 6:30529 (2016). WB ; Mouse . PubMed: 27456665