Overview

  • Product name

    Vitamin B12, cofactor of methionine synthase
  • Description

    Water soluble vitamin. Cofactor of methionine synthase.
  • Biological description

    Water soluble vitamin. Cofactor of methionine synthase. Enables mammalian cellular replication from synthesis of proteins and nucleic acids in vivo. Involved in normal functioning of the nervous system. Orally active.
  • Purity

    > 99%
  • CAS Number

    68-19-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(2R,3S,4R)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]
    [(2R)-1-[3-[(1R,2R,3R,5Z,7S,10Z,12S,13S,15Z,17S,18S,19R)-2,13,
    18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl]
    phosphate cyanide cobalt(3+)
  • Molecular weight

    1355.37
  • Molecular formula

    C63H88CoN14O14P
  • PubChem identifier

    16212801
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM and in DMSO to 50 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kozyraki R & Cases O Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders. Biochimie 95:1002-7 (2013). Read more (PubMed: 23178706) »
  • Guéant JL  et al. Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. Biochimie 95:1033-40 (2013). Read more (PubMed: 23415654) »
  • Sysel AM  et al. Immunohistochemical quantification of the vitamin B12 transport protein (TCII), cell surface receptor (TCII-R) and Ki-67 in human tumor xenografts. Anticancer Res 33:4203-12 (2013). Read more (PubMed: 24122983) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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