Overview

  • Product name

    Anti-Vitamin D Receptor antibody
    See all Vitamin D Receptor primary antibodies
  • Description

    Rabbit polyclonal to Vitamin D Receptor
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISA, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to an internal sequence of Human Vitamin D Receptor.

  • Positive control

    • Human Skin tissue; HeLa cells; MCF7 cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab134826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 48 kDa.
ELISA 1/10000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

Target

  • Function

    Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
  • Involvement in disease

    Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Domain

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1 25 dihydroxyvitamin D3 receptor antibody
    • 1 antibody
    • 1,25 dihydroxyvitamin D3 receptor antibody
    • 1,25-@dihydroxyvitamin D3 receptor antibody
    • 25-dihydroxyvitamin D3 receptor antibody
    • Member 1 antibody
    • NR1I1 antibody
    • Nuclear receptor subfamily 1 group I member 1 antibody
    • PPP1R163 antibody
    • Protein phosphatase 1, regulatory subunit 163 antibody
    • VDR antibody
    • VDR_HUMAN antibody
    • Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
    • Vitamin D hormone receptor antibody
    • Vitamin D nuclear receptor variant 1 antibody
    • Vitamin D receptor antibody
    • Vitamin D3 receptor antibody
    see all

Images

  • All lanes : Anti-Vitamin D Receptor antibody (ab134826) at 1/500 dilution

    Lane 1 : MCF7 cell extracts
    Lane 2 : MCF7 cell extracts with synthesized peptide

    Predicted band size: 48 kDa

  • Immunofluorescence analysis of HeLa cells labelling Vitamin D Receptor with ab134826 at 1/100 dilution. The image on the right is treated with the synthesized peptide.
  • Immunohistochemical analysis of Formalin-fixed, Paraffin-embedded Human Skin tissue labelling Vitamin D Receptor with ab134826 at 5 µg/ml.

References

This product has been referenced in:

  • Sun W  et al. 'Psoriasis 1' reduces psoriasis-like skin inflammation by inhibiting the VDR-mediated nuclear NF-?B and STAT signaling pathways. Mol Med Rep 18:2733-2743 (2018). Read more (PubMed: 30015892) »
See 1 Publication for this product

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