Anti-VNN1/Vanin-1 antibody (ab205912)
Key features and details
- Rabbit polyclonal to VNN1/Vanin-1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-VNN1/Vanin-1 antibody
See all VNN1/Vanin-1 primary antibodies -
Description
Rabbit polyclonal to VNN1/Vanin-1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human VNN1/Vanin-1 aa 300-500. (BC096268).
Database link: O95497 -
Positive control
- HepG2 lysate; Human fetal spleen tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute in 200ul sterile H2O. -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab205912 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/200 - 1/1000. Predicted molecular weight: 57 kDa.
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/200 - 1/1000. Predicted molecular weight: 57 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. -
Tissue specificity
Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. -
Sequence similarities
Belongs to the CN hydrolase family. BTD/VNN subfamily.
Contains 1 CN hydrolase domain. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 8876 Human
- Omim: 603570 Human
- SwissProt: O95497 Human
- Unigene: 12114 Human
- Unigene: 720659 Human
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Alternative names
- HDLCQ8 antibody
- High density lipoprotein cholesterol level quantitative trait locus 8, included antibody
- Pantetheinase antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab205912 has been referenced in 4 publications.
- Yu W et al. Upregulated Vanins and their potential contribution to periodontitis. BMC Oral Health 22:614 (2022). PubMed: 36527111
- Xing Y et al. Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NF?B-mediated inflammation in IUGR mice. Biol Open 9:N/A (2020). PubMed: 32139393
- Ling L et al. MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1. Kidney Blood Press Res 44:565-582 (2019). PubMed: 31340209
- Chai CY et al. VNN1 overexpression is associated with poor response to preoperative chemoradiotherapy and adverse prognosis in patients with rectal cancers. Am J Transl Res 8:4455-4463 (2016). IHC ; Human . PubMed: 27830030