Key features and details
- Rabbit polyclonal to VPS13B/CHS1
- Suitable for: ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-VPS13B/CHS1 antibody
DescriptionRabbit polyclonal to VPS13B/CHS1
SpecificityAt least five alternatively spliced transcript variants have been observed. ab139814 detects two isoforms.
Tested applicationsSuitable for: ICC/IF, WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human VPS13B/CHS1 (N terminal).
Database link: NP_056058
- SK-N-SH cell lysate.
This product was previously labelled as VPS13B
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab139814 was purified by affinity chromatography via a peptide column.
Our Abpromise guarantee covers the use of ab139814 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 20 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 97, 159 kDa.|
FunctionMay be involved in protein sorting in post Golgi membrane traffic.
Tissue specificityWidely expressed. There is apparent differential expression of different transcripts. In fetal brain, lung, liver, and kidney, two transcripts of 2 and 5 kb are identified. These transcripts are also seen in all adult tissues analyzed. A larger transcript (12-14 kb) is expressed in prostate, testis, ovary, and colon in the adult. Expression is very low in adult brain tissue. Isoform 1 and isoform 2 are expressed in brain and retina. Isoform 2 is expressed ubiquitously.
Involvement in diseaseDefects in VPS13B are a cause of Cohen syndrome (COH1) [MIM:216550]. COH1 is a rare autosomal recessive disorder characterized by obesity, hypotonia, intellectual deficit, characteristic craniofacial dysmorphism and abnormalities of the hands and feet. Characteristic facial features include high-arched or wave-shaped eyelids, a short philtrum, thick hair and low hairline.
Sequence similaritiesBelongs to the VPS13 family.
- Information by UniProt
- CHS1 antibody
- COH1 antibody
- Cohen syndrome protein 1 antibody
ab139814 has not yet been referenced specifically in any publications.