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    vps13bchs1-antibody-ab139814.pdf

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Signal Transduction Protein Trafficking Golgi Proteins
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Anti-VPS13B/CHS1 antibody (ab139814)

  • Datasheet
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Immunocytochemistry/ Immunofluorescence - Anti-VPS13B/CHS1 antibody (ab139814)
  • Western blot - Anti-VPS13B/CHS1 antibody (ab139814)

Key features and details

  • Rabbit polyclonal to VPS13B/CHS1
  • Suitable for: ICC/IF, WB
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-VPS13B/CHS1 antibody
  • Description

    Rabbit polyclonal to VPS13B/CHS1
  • Host species

    Rabbit
  • Specificity

    At least five alternatively spliced transcript variants have been observed. ab139814 detects two isoforms.
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human VPS13B/CHS1 (N terminal).
    Database link: NP_056058

  • Positive control

    • SK-N-SH cell lysate.
  • General notes

     This product was previously labelled as VPS13B

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab139814 was purified by affinity chromatography via a peptide column.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Protein Trafficking
    • Golgi Proteins

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • SK N SH whole cell lysate (ab3956)

Applications

Our Abpromise guarantee covers the use of ab139814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 97, 159 kDa.

Target

  • Function

    May be involved in protein sorting in post Golgi membrane traffic.
  • Tissue specificity

    Widely expressed. There is apparent differential expression of different transcripts. In fetal brain, lung, liver, and kidney, two transcripts of 2 and 5 kb are identified. These transcripts are also seen in all adult tissues analyzed. A larger transcript (12-14 kb) is expressed in prostate, testis, ovary, and colon in the adult. Expression is very low in adult brain tissue. Isoform 1 and isoform 2 are expressed in brain and retina. Isoform 2 is expressed ubiquitously.
  • Involvement in disease

    Defects in VPS13B are a cause of Cohen syndrome (COH1) [MIM:216550]. COH1 is a rare autosomal recessive disorder characterized by obesity, hypotonia, intellectual deficit, characteristic craniofacial dysmorphism and abnormalities of the hands and feet. Characteristic facial features include high-arched or wave-shaped eyelids, a short philtrum, thick hair and low hairline.
  • Sequence similarities

    Belongs to the VPS13 family.
  • Target information above from: UniProt accession Q7Z7G8 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 157680 Human
    • Entrez Gene: 666173 Mouse
    • Entrez Gene: 315036 Rat
    • Omim: 607817 Human
    • SwissProt: Q7Z7G8 Human
    • SwissProt: Q80TY5 Mouse
    • Unigene: 191540 Human
    • Alternative names

      • CHS1 antibody
      • COH1 antibody
      • Cohen syndrome protein 1 antibody
      • Vacuolar protein sorting 13 homolog B (yeast) antibody
      • Vacuolar protein sorting-associated protein 13B antibody
      • VP13B_HUMAN antibody
      • vps13B antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-VPS13B/CHS1 antibody (ab139814)
      Immunocytochemistry/ Immunofluorescence - Anti-VPS13B/CHS1 antibody (ab139814)

      Immunofluorescence of VPS13B/CHS1 in Human brain tissue with ab139814 at 20 ug/mL.

    • Western blot - Anti-VPS13B/CHS1 antibody (ab139814)
      Western blot - Anti-VPS13B/CHS1 antibody (ab139814)
      Lane 1 : Anti-VPS13B/CHS1 antibody (ab139814) at 1 µg/ml
      Lane 2 : Anti-VPS13B/CHS1 antibody (ab139814) at 2 µg/ml

      All lanes : SK-N-SH cell lysate

      Lysates/proteins at 15 µg per lane.

      Predicted band size: 97, 159 kDa

    Protocols

    • Western blot protocols
    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab139814? Please let us know so that we can cite the reference in this datasheet.

    ab139814 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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