Overview

  • Product name
  • Description
    Rabbit polyclonal to VPS33B
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus tropicalis
  • Immunogen

    Recombinant fragment corresponding to a region within internal sequence amino acids 224-502 of Human VPS33B.

  • Positive control
    • 293T, A431, HeLa and HepG2 whole cell lysates; U87 xenograft.

Properties

Applications

Our Abpromise guarantee covers the use of ab153844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 71 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Relevance
    VPS33B belongs to the STXBP/unc-18/SEC1 family. It may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. VPS33B is ubiquitous; highly expressed in testis and low expression in the lung. Defects in VPS33B are the cause of arthrogryposis-renal dysfunction-cholestasis syndrome (ARC) [MIM:208085]. ARC is an autosomal recessive multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common.
  • Cellular localization
    Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles.
  • Database links
  • Alternative names
    • FLJ14848 antibody
    • hVPS 33B antibody
    • hVPS33B antibody
    • Vacuolar protein sorting 33 homolog B (yeast) antibody
    • Vacuolar protein sorting 33 homolog B antibody
    • Vacuolar protein sorting 33B (yeast) antibody
    • Vacuolar protein sorting 33B antibody
    • Vacuolar protein sorting associated protein 33B antibody
    • VPS 33B antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded U87 xenograft labeling VPS33B with ab153844 at 1/500 dilution.
  • All lanes : Anti-VPS33B antibody (ab153844) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : HeLa whole cell lysate
    Lane 4 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 71 kDa



    7.5% SDS PAGE

References

ab153844 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab153844.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up