• Product name

  • Description

    Rabbit polyclonal to VR1
  • Host species

  • Tested applications

    Suitable for: IHC (PFA fixed), IHC-P, IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Guinea pig
  • Immunogen

    Synthetic peptide:


    conjugated to KLH, corresponding to C terminal amino acids 825 - 839 of Mouse TRPV1



Our Abpromise guarantee covers the use of ab31895 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC (PFA fixed) 1/1000.
IHC-P 1/1000.
IHC-Fr 1/400. PubMed: 19153713


  • Function

    Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
  • Tissue specificity

    Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
  • Sequence similarities

    Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
    Contains 6 ANK repeats.
  • Domain

    The association domain (AD) is necessary for self-association.
  • Post-translational

    Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
  • Cellular localization

    Cell junction > synapse > postsynaptic cell membrane. Cell projection > dendritic spine membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Capsaicin receptor antibody
    • DKFZp434K0220 antibody
    • osm 9 like TRP channel 1 antibody
    • Osm-9-like TRP channel 1 antibody
    • OTRPC1 antibody
    • Transient receptor potential cation channel subfamily V member 1 antibody
    • TRPV 1 antibody
    • Trpv1 antibody
    • TRPV1_HUMAN antibody
    • Vanilloid receptor 1 antibody
    • Vanilloid receptor subtype 1 antibody
    • VR 1 antibody
    • VR1 antibody
    see all


  • ab31895 at 1/1000 demonstrating VR1 immunoreactivity in mouse dorsal root ganglion. Animals were perfusion fixed with 2% paraformaldehyde.
  • ab31895 staining mouse inferior olive using Cy3-conjugated donkey anti-rabbit secondary antibodies (red color) and DAPI (blue) as a nuclear counterstain.


This product has been referenced in:

  • Minami A  et al. Hyperbaric oxygen significantly improves frequent urination, hyperalgesia, and tissue damage in a mouse long-lasting cystitis model induced by an intravesical instillation of hydrogen peroxide. Neurourol Urodyn 38:97-106 (2019). Read more (PubMed: 30411813) »
  • Weber L  et al. The Development of a Macromolecular Analgesic for Arthritic Pain. Mol Pharm 16:1234-1244 (2019). Read more (PubMed: 30702897) »
See all 21 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Western blot
Mouse Tissue lysate - whole (olfactory epithelium)
Loading amount
40 µg
olfactory epithelium
Gel Running Conditions
Non-reduced Non-Denaturing (Native) (12.5%)
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 20°C

Abcam user community

Verified customer

Submitted Oct 05 2011


Thank you for contacting us. I understand your customer's concerns regarding the anti-VR1 antibody ab31895. Please be assured that the observed precipitation sometimes happens for whole antiserum antibodies and there is no problem with the quality of this product. We would recommend to briefly centrifuge the aliquot and to use the clear supernatant. The antibody can then be used as usual. Of course, we will be pleased to provide a free of charge replacement, credit note or refund, if it then turns out that the antibody is not functioning in the applications cited on the product data sheet. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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