Product nameAnti-VRL1 antibody
See all VRL1 primary antibodies
DescriptionRabbit polyclonal to VRL1
SpecificityImmunohistochemical analysis of rat dorsal root ganglia and spinal cord indicates high level of specificity for this antiserum. Cross reactivity: This antibody is known to react with rat. Other species have not been tested yet.
Tested applicationsSuitable for: IHC-Frmore details
Species reactivityReacts with: Rat
General notesThis antibody is excellent for immunohistochemistry. It stains a subpopulation of neurons in the rat dorsal root ganglia. VRL 1 is also known as Vanilloid Receptor Like protein-1.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Our Abpromise guarantee covers the use of ab6182 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Western Blot: Not tested.
Immunoblot: Not tested.
1 site ELISA: Not tested.
Biological Inhibition: Not tested.
FunctionCalcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
Sequence similaritiesBelongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Contains 6 ANK repeats.
Phosphorylated by PKA.
Cellular localizationCell membrane. Cytoplasm. Melanosome. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
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ab6182 has not yet been referenced specifically in any publications.