Overview

  • Product name

    VU 0238429, allosteric M5 modulator
  • Description

    Selective, positive allosteric M5 modulator
  • Biological description

    Selective, positive allosteric M5 modulator (EC50 values are 1.16 and >30 μM at M5 and M1/ M3 receptors, respectively). Shows no activity at M2 and M4 receptors.
  • Purity

    > 99%
  • CAS Number

    1160247-92-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
  • Molecular weight

    351.28
  • Molecular formula

    C17H12F3NO4
  • PubChem identifier

    42633508
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    FC(F)(F)Oc1cc3c(cc1)N(Cc2ccc(OC)cc2)C(=O)C3=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bridges TM  et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem 52:3445-8 (2009). Read more (PubMed: 19438238) »

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